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KMID : 0811720170210040415
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Korean Journal of Physiology & Pharmacology
2017 Volume.21 No. 4 p.415 ~ p.421
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Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells
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Kim Han-Sol
Li Hong Liang
Kim Hye-Won
Shin Sung-Eun
Seo Mi-Seon
An Jin-Ryeol
Ha Kwon-Soo
Han Eun-Taek
Hong Seok-Ho
Choi Il-Whan
Choi Grace
Park Won-Sun
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Abstract
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We investigated the inhibitory effect of escitalopram, a selective serotonin reuptake inhibitor (SSRI), on voltage-dependent K+ (Kv) channels in freshly separated from rabbit coronary arterial smooth muscle cells. The application of escitalopram rapidly inhibited vascular Kv channels. Kv currents were progressively inhibited by an increase in the concentrations of escitalopram, suggesting that escitalopram inhibited vascular Kv currents in a concentration-dependent manner. The IC50 value and Hill coefficient for escitalopram-induced inhibition of Kv channels were 9.54±1.33 μM and 0.75±0.10, respectively. Addition of escitalopram did not alter the steady-state activation and inactivation curves, suggesting that the voltage sensors of the channels were not affected. Pretreatment with inhibitors of Kv1.5 and/or Kv2.1 did not affect the inhibitory action of escitalopram on vascular Kv channels. From these results, we concluded that escitalopram decreased the vascular Kv current in a concentration-dependent manner, independent of serotonin reuptake inhibition.
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KEYWORD
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Coronary artery, Escitalopram, Serotonin reuptake inhibition, Smooth muscle, Voltage-dependent K+ channel
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